The short version of AEDG fits in a sentence. The long version — which is the one that helps — is below.
Reviewed 2025-11-06. Anything still debated is marked as such rather than presented as settled.
The peptide is a synthetic analogue of epithalamin, a preparation extracted from bovine pineal glands. Investigators sought a short, chemically defined molecule that would reproduce some of the endocrine and gerontological observations attributed to the glandular extract. Proposed mechanisms centre on induction of telomerase activity, an effect reported in cultured human somatic cells in the early 2000s, together with influences on melatonin secretion and neuroendocrine regulation. Those mechanisms remain incompletely characterised, and the reported telomerase response has not been consistently reproduced by independent groups working in comparable systems.
Published work on this compound consists mainly of in vitro experiments, animal studies, and small clinical investigations, a substantial share of which appeared in Russian-language journals. Sample sizes are generally small, control conditions differ between studies, and several endpoints rely on markers whose clinical meaning is itself debated. Reviews of the longevity field treat the peptide as an early example of telomerase-directed research rather than an established intervention. Regulatory treatment varies by country: some jurisdictions place it under prescription controls, others treat it as a laboratory material, and importation may be restricted regardless of local status.
Epitalon is a synthetic tetrapeptide whose sequence is alanine–glutamate–aspartate–glycine, commonly abbreviated AEDG. It was developed in Russia during the 1980s and 1990s by investigators associated with the St. Petersburg Institute of Bioregulation and Gerontology, who studied short peptides as regulators of gene expression and tissue function. The alternative spelling epithalon appears interchangeably in the literature, and the two names refer to the same molecule. Outside Russia it is encountered chiefly as a research chemical rather than a licensed medicine, and it holds no approval from the United States Food and Drug Administration or the European Medicines Agency.
Residue composition is the property that most cleanly separates verified material from mislabelled samples. Alanine, glutamate, aspartate and glycine appear in that order from the N-terminus, and the two acidic residues sit in the middle of the chain. Because the peptide is short, it can be produced by solid-phase synthesis and characterised by mass spectrometry without ambiguity. Any reported sample whose measured mass departs substantially from 390 daltons is a different compound or a degraded mixture rather than epitalon.
Epitalon is a synthetic tetrapeptide whose four residues are alanine, glutamate, aspartate and glycine, commonly abbreviated AEDG. Its molecular formula is C14H22N4O9 and its monoisotopic mass is near 390.35 daltons. The peptide carries two acidic side chains, so it is neutral to negatively charged in most aqueous buffers. Published reference summaries usually list it under both spellings, epitalon and epithalon, and treat the two names as the same material.
| Property | Value | Notes |
|---|---|---|
| Peptide sequence | Ala-Glu-Asp-Gly | Often abbreviated AEDG in research literature |
| Common synonyms | Epithalon, epitalon, AEDG | Spelling variants refer to the same tetrapeptide |
| Molecular formula | C14H22N4O9 | Theoretical monoisotopic mass near 390.35 Da |
| Appearance | White to off-white powder | Typically supplied as a lyophilised solid |
| Solubility class | Freely soluble in water | Hydrophilic peptide; dissolves in aqueous buffer |
The compound is described in the literature as a derivative of epithalamin, a preparation obtained from bovine pineal tissue. Work on this peptide family was carried out mainly by a research group in Saint Petersburg beginning in the 1980s, and the substance was later registered for clinical use in Russia under the name Epitalon. Outside that region it is generally treated as a research chemical rather than an approved medicine. Statements about its biological activity rest on a relatively small number of studies, and independent replication remains limited.
In its supplied form epitalon is a white to off-white powder, usually lyophilized and often hygroscopic. It dissolves readily in water and in aqueous buffers, and it is commonly handled as the acetate or trifluoroacetate salt to improve stability during purification and drying. The amide backbone is labile in aqueous media, so solutions are less durable than the dry solid. Handling notes in the chemical literature therefore emphasize keeping the powder dry, cool and shielded from light until it is dissolved.
Material supplied for laboratory use is normally a lyophilised white to off-white powder that dissolves readily in water and in isotonic saline. Lyophilised cakes are hygroscopic and should be equilibrated to room temperature before opening to limit condensation on the solid. Solutions are typically prepared at milligram-per-millilitre concentrations and divided into single-use aliquots, because repeated freeze–thaw cycles degrade short peptides. Aqueous solutions are far less stable than the dry powder, and identity is usually verified by mass spectrometry alongside purity estimation from reversed-phase high-performance liquid chromatography.
Epitalon is a synthetic linear tetrapeptide with the sequence alanine–glutamate–aspartate–glycine, abbreviated AEDG. Its molecular formula is C14H22N4O9 and the calculated mass is approximately 390.35 g/mol. The compound is made by solid-phase peptide synthesis rather than extracted from tissue, although early work described it as a short fragment of a peptide fraction obtained from bovine pineal extract. In the research literature the spelling epitalon and the variant epithalone both appear, while AEDG is the standard code used in peptide nomenclature.
The sale allows TGI Fridays to repay its $23.9 million bankruptcy loan, with about $8 million in cash left over. On January 29, 2025, it was announced TGI Fridays UK's flagship restaurant in Leicester Square, London, had closed down. On January 30, 2025, it was reported that 30 more locations had closed, which left the chain with only around 100 locations remaining in the US. On February 3, 2025, it was announced that 19 of TGI Fridays' corporate-owned restaurants had been sold to two separate franchisees: three to Sugarloaf Hospitality and 16 to Yadav Enterprises, and that TGI Fridays had rejected the leases for six more restaurants. On 31 October 2025, it was announced that Sugarloaf TGIF Management had acquired TGI Friday's 49 UK restaurants from Calveton UK and Breal Capital as part of an international consolidation of the brand under Ray Blanchette. Sugarloaf is establishing a UK-led management team for the restaurants. However, less than three months later, on 14 January 2026, TGI Fridays closed 16 restaurants and went into administration for the second time in a year.
=== Cephalosporins === After the war ended, Florey directed his team at the Sir William Dunn School in the investigation of antibiotic substances produced by plants and microorganisms. They studied claviformin, proactinomycin, helvolic acid, mycophenolic acid, hirsutic acid, bacitracin and micrococcin. In 1949, they published Antibiotics: A Survey of Penicillin, Streptomycin, and Other Antimicrobial Substances from Fungi, Actinomycetes, Bacteria and Plants, a massive two-volume work. Florey also edited Lectures on General Pathology, which was published in 1954. Chain departed in 1948, but Guy Newton joined the team in his place as its biochemist. Financial support came from the Medical Research Council, the Albert and Mary Lasker Foundation, and American pharmaceutical companies. In September 1953 Newton and Abraham isolated crystalline cephalosporin C from a fungus originally isolated by Giuseppe Brotzu in Sardinia, and found that it had antibiotic properties. Their initial evaluation of the antibiotic activity of cephalosporin C was that it was low, so Abraham sent Florey, who was in Australia, a letter asking if research should continue. Florey saw an intellectually challenging line of research, and told them to continue. They found that it was resistant to penicillinase produced by gram-positive bacteria. When he returned to Oxford, Florey and Jennings conducted a series of experiments that determined that it was not toxic to mice but could protect them against streptococci and penicillinase-producing staphylococci.
The Society recognizes achievements and promotes academic research through four annual awards. The Biemann Medal and the John B. Fenn Award for a Distinguished Contribution in Mass Spectrometry both are awarded in recognition of singular achievements or contributions in fundamental or applied mass spectrometry, with the Biemann Medal being focused on individuals who are early in their careers. The Ronald A. Hites Award is awarded for outstanding original research demonstrated in papers published in the Journal of the American Society for Mass Spectrometry. The Research Awards are given to young scientists in mass spectrometry, based on the evaluation of their proposed research. The Fellows of ASMS are awarded to individuals in recognition for their scientific contribution to mass spectrometry and for their contribution to the ASMS community. Journal of the American Society for Mass Spectrometry Measuring Mass: From Positive Rays to Proteins The past presidents of ASMS are:
=== Spectrometer === Americium-241 has been used as a portable source of both gamma rays and alpha particles for a number of medical and industrial uses. The 59.5409 keV (9.53950 fJ) gamma ray emissions from 241Am in such sources can be used for indirect analysis of materials in radiography and X-ray fluorescence spectroscopy, as well as for quality control in fixed nuclear density gauges and nuclear densometers. For example, this isotope has been employed to gauge glass thickness to help create flat glass. Americium-241 is also suitable for calibration of gamma-ray spectrometers in the low-energy range, since its spectrum consists of nearly a single peak and negligible Compton continuum (at least three orders of magnitude lower intensity).
Although the error rate for both whites and blacks was calibrated equal at exactly 61%, the errors for each race were different—the system consistently overestimated the chance that a black person would re-offend and would underestimate the chance that a white person would not re-offend. In 2017, several researchers showed that it was mathematically impossible for COMPAS to accommodate all possible measures of fairness when the base rates of re-offence were different for whites and blacks in the data. A program can make biased decisions even if the data does not explicitly mention a problematic feature (such as "race" or "gender"). The feature will correlate with other features (like "address", "shopping history" or "first name"), and the program will make the same decisions based on these features as it would on "race" or "gender". Moritz Hardt said "the most robust fact in this research area is that fairness through blindness doesn't work." Criticism of COMPAS highlighted that machine learning models are designed to make "predictions" that are only valid if we assume that the future will resemble the past. If they are trained on data that includes the results of racist decisions in the past, machine learning models must predict that racist decisions will be made in the future. If an application then uses these predictions as recommendations, some of these "recommendations" will likely be racist. Thus, machine learning is not well suited to help make decisions in areas where there is hope that the future will be better than the past.
Sources: en.wikipedia.org
The association between nucleotide excision repair capability and longevity is strengthened by the evidence that defects in nucleotide excision repair proteins in humans and rodents cause features of premature aging, as reviewed by Diderich. Further support for the theory that DNA damage is the primary cause of aging comes from study of Poly ADP ribose polymerases (PARPs). PARPs are enzymes that are activated by DNA strand breaks and play a role in DNA base excision repair. Burkle et al. reviewed evidence that PARPs, and especially PARP-1, are involved in maintaining mammalian longevity. The life span of 13 mammalian species correlated with poly(ADP ribosyl)ation capability measured in mononuclear cells. Furthermore, lymphoblastoid cell lines from peripheral blood lymphocytes of humans over age 100 had a significantly higher poly(ADP-ribosyl)ation capability than control cell lines from younger individuals.
Episcleritis is a benign, self-limiting inflammatory disease affecting part of the eye called the episclera. The episclera is a thin layer of tissue that lies between the conjunctiva and the connective tissue layer that forms the white of the eye (sclera). Episcleritis is a common condition, and is characterized by the abrupt onset of painless eye redness. There are two types of episcleritis, nodular and simple. Nodular episcleritis lesions have raised surface. Simple episcleritis lesions are flat. There are two subtypes. In diffuse simple episcleritis, inflammation is generalized. In sectoral simple episcleritis, the inflammation is restricted to one region. Most cases of episcleritis have no identifiable cause, although about a third of cases are associated with various systemic diseases. Often people with episcleritis experience it recurrently. Treatment focuses on decreasing discomfort, and includes lubricating eye drops. More severe cases may be treated with topical corticosteroids or oral anti-inflammatory medications (NSAIDs).
The 3D framework [Cu3(btc)2(H2O)3] (btc: benzene-1,3,5-tricarboxylate) (HKUST-1) used in this study was first reported by Williams et al. The open framework of [Cu3(btc)2(H2O)3] is built from dimeric cupric tetracarboxylate units (paddle-wheels) with aqua molecules coordinating to the axial positions and btc bridging ligands. The resulting framework after removal of two water molecules from axial positions possesses porous channel. This activated MOF catalyzes the trimethylcyanosilylation of benzaldehydes with a low conversion (<5% in 24 h) at 293 K. As the reaction temperature was raised to 313 K, a good conversion of 57% with a selectivity of 89% was obtained after 72 h. In comparison, less than 10% conversion was observed for the background reaction (without MOF) under the same conditions. But this strategy suffers from some problems like 1) the decomposition of the framework with increase of the reaction temperature due to the reduction of Cu(II) to Cu(I) by aldehydes; 2) strong solvent inhibition effect; electron donating solvents such as THF competed with aldehydes for coordination to the Cu(II) sites, and no cyanosilylation product was observed in these solvents; 3) the framework instability in some organic solvents. Several other groups have also reported the use of metal centres in MOFs as catalysts. Again, electron-deficient nature of some metals and metal clusters makes the resulting MOFs efficient oxidation catalysts. Mori and coworkers reported MOFs with Cu2 paddle wheel units as heterogeneous catalysts for the oxidation of alcohols.
The Prime Minister of Spain at the time, Práxedes Mariano Mateo Sagasta y Escolar, was also a Freemason. It was also in Madrid, and not in Cuba, where José Martí was in the 1870's initiated as a Freemason into Logia Armonía (English: Harmony Lodge).
Sources: en.wikipedia.org
== History == The Dutch introduced cold brew coffee to Japan, where it has been a traditional method of coffee brewing for centuries. Slow-drip Cold brew refers to a process in which water is dripped through coffee grounds at room temperature over the course of many hours. It has been called "Kyoto-style", or in East Asia "Dutch coffee".
== See also == List of pre-Columbian cultures Domesticated plants of Mesoamerica Agriculture in Mesoamerica Mesoamerican cuisine Mesoamerican diet and subsistence Mesoamerican architecture Indigenous music of North America Painting in the Americas before European colonization Mesoamerican chronology History portal North America portal Central America portal South America portal
== Pharmacology == Not much is understood about how benzoctamine produces its anti-anxiety effects, but rat studies have shown that the possible mechanism of action is by way of increased turnover of catecholamines. In addition to serotonin it has also been shown to decrease epinephrine, dopamine, and norepinephrine turnover by antagonizing their receptors. When given intravenously in doses of 20–40 mg there are no significant differences in efficacy. Oral doses exceeding 10 mg three times daily do not increase the effects of the drug. Assuming serotonin postsynaptic antagonism is the main mechanism by which benzoctamine carries out its effects, studies have shown it to have an IC50 value of 115 mM at the serotonin receptor.
The amino acid positions of population variants and variants with known clinical relevance in the Ensembl Variation database as well as predicted benign and pathological variants from AlphaMissense can also be displayed.. The Interaction resource focuses on various aspects of human protein interactions, including reported experimental protein-protein interactions and their prediced three-dimensional structures as well as metabolic interactions and pathways. The data is based on external sources complemented with "in-house" analysis. Here you can explore: - Predicted 3D structures for consensus protein-protein interactions - Protein-protein interaction networks for most genes - Features such as subcellular location and expression specificity displayed on the interaction networks - Pathways/subsystems of metabolic genes and metabolic pathways from the Metabolic Atlas.
buffered solution Also simply called a buffer. An aqueous solution consisting of a weak acid and its conjugate base or a weak base and its conjugate acid that resists changes in pH when strong acids or bases are added.
Sources: en.wikipedia.org
Epitalon is a synthetic four-amino-acid peptide with the sequence alanine–glutamate–aspartate–glycine, also written AEDG. It was developed in Russian gerontology research and is studied for proposed effects on telomerase, melatonin regulation, and neuroendocrine function. It is not an approved pharmaceutical in the United States or the European Union.
No. Epithalamin is a peptide-rich extract prepared from bovine pineal glands, while epitalon is a short synthetic peptide designed as a defined analogue of it. The synthetic version was intended to provide a reproducible molecule with some of the same proposed biological activity.
Telomere elongation and telomerase activation have been reported in cultured human somatic cells, but evidence from living human subjects is limited and has not been independently confirmed at scale. Reported findings come largely from small studies with differing designs, so the question remains open rather than settled.
It is a four-amino-acid peptide built from alanine, glutamate, aspartate and glycine in that order. Its formula is C14H22N4O9, and it is made by chemical synthesis rather than extracted from tissue. The synthetic peptide is a single defined molecule, unlike the pineal extracts it is often compared with.